One such variant, called “e4”, is known to affect cholesterol levels and processes involved in inflammation, as well as increasing the risk of heart disease and dementia. “It is possible that the role of ApoE in the immune system is important in the disease and future research may be able to harness this to develop effective treatments,” she said. Fiona Carragher, a director of research and influencing at Alzheimer’s Society, said people with dementia and their families were desperately worried, adding the government must take urgent action to protect people with dementia. But clearly much more in-depth research is urgently needed to fully understand why people with dementia seem to be at a higher risk and to what extent factors like ethnicity and genetics might play a role,” she said.“I’m afraid this study does not really convince me that the ApoE e4 allele [gene variant] is really an independent risk factor for severe Covid-19 infection,” he said.
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